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  1. Hvor mange trengs for majoritet..? Spiller det, noen rolle om så, 7 milliarder republikaner hade trott på det?
  2. "The results from a study show age-dependent expression of ACE2 in nasal epithelium, the first point of contact for SARS-CoV-2 and the human body," Man må skjønne at ACE2 er viktig i immuneresponser mot virus, først og fremst. Og de finnes i ulike steder av kroppen. Det de har funnit, er mindre antal ACE2 i "nasal epithelium" hos barn, og mer ju eldre man blir. Der skjer første kontakten med Covid-19. SARS-CoV-2 trenger ACE2, for at komme inn i kroppen, først og fremst. Når den vel er inne i kroppen hemmer, deaktiverer, Covid-19, ACE2:s arbeid. Litt historia: ACE2 genen er en så kalt "escaped gene". Den kommer fra kvinnen. Det er en x kromosome gen. Kvinner har dobbel oppsett av alt da de har to (XX) og menn har bare enn (XY) Kvinner får/arver sin ene X kromosom fra mor, og sin andre X fra sin fars mor. Farmor. Hvorfor den kalles "escaped gene" er for at i kvinnen blir en av kromosomerna (X) deaktivert i dna. Sånn att de bare har 1 oppsett av alle gener. Dette skjer i embryot. Men ACE2 tilhør en av generna som av noen anledning kommer undan denne prosessen. Finnes flere. Så kvinnen har 2, ACE2 typer, aktiva i sin kropp. Dette ser man som en stor fordel i kampen mot virus/patogener, da mannen har bare 1 type av ACE2. Noen varianter av ACE2 "matcher" proteinet som Covid-19 benytter seg av for og ta seg inn i kroppen bedre enn andre varianter. Man har forsket på forskjeller på typer av ACE2 og funnit at Italiensk population og Asiatisk population har en ACE2 type som Covid-19 lettere tar seg inn gjennom. "in females’ cells, 50 percent are going to be using likely a slightly different version of the ACE2 than other cells. It’s much more difficult for a strain of corona to have a spike protein that could equally infect both populations of cells"https://www.discovermagazine.com/health/the-reason-more-men-die-from-covid-19-may-lie-in-their-chromosomes Litt annen historie i mellom det, betakoronavirus kommer fra Flaggermusen, men ACE2 kommer fra foreldrene: ( blir litt sånn, når man surfer og tenker! : De som er eldre, og mest sårbare er fra 70-90 år og oppover. De føddes på 1930-50 tal. Deres foreldrer levde da i tiden fra, 1910-1930. Dette var en stor tid for luftfart (Pioneer era,1903-1914) Santos-Dumont tegnet, bygde og fløy det første praktiske styrbare luftskip. The Santos-Dumont's, Demoiselle (nr.19) was a series of aircraft built in France by world aviation pioneer Alberto Santos-Dumont. The name of the Demoiselle aircraft is a synonym for "jeune fille"—young girl or woman—but also the common name in French for a Damselfly (vannymfe) The Demoiselle No 19 could be constructed in only 15 days and became the world's first series production aircraft. "jeune fille", Adolescens (lat adolescere = (att) växa upp, tillväxa) är övergångsperioden mellan att vara ett barn och att vara vuxen; åren efter puberteten. Demo: (music), a song recorded for reference rather than release The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) The pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once. These 4 are the -viral loop -the hyperinflammatory loop -the non-canonical renin-angiotensin system (RAS) axis loop -the hypercoagulation loop The viral feedback loop includes evading the host’s innate response, uncontrolled viral replication, and turning on a hyperactive adaptative immune response The inflammatory loop is composed of the exuberant inflammatory response feeding back until exploding in an actual cytokine storm. Downregulation of the ACE2/Ang-(17)/Mas1R axis leaves the lung without a critical defense mechanism and turns the scale to the inflammatory side of the RAS The coagulation loop is a hypercoagulable state caused by the interplay between inflammation and coagulation in an endless feedback loop. The result is a hyperinflammatory and hypercoagulable state producing acute immune-mediated lung injury and eventually, adult respiratory distress syndrome. ..."Sometimes the pathogen (virus) could be a mere initiator more than an actual perpetrator and it is the host’s (patients) forces unchained by the pathogen’s presence, those which are to cause tissue and organ damage. The first horseman: a sneaky virus (viral loop) SARS-CoV-2, like SARS-CoV, requires the ACE2 as a receptor to enter the cells. After the virus entry, the RNA genome (of virus) is released into the cytoplasm and translated into two polyproteins and structural proteins. The survival of SARS-CoV in host cells is eased by strategies to evade the immune response. - SARS-CoV induces the production of double-membrane vesicles that lack PRRs and can then replicate in these vesicles. What are PAMPs and PRRs? Summary: The innate immune system constitutes the first line of defense against invading microbial pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect distinct evolutionarily conserved structures on pathogens, termed pathogen-associated molecular patterns (PAMPs). - Furthermore, several structural and nsps encoded by SARS-CoV and MERS-CoV antagonize antiviral innate immune response. Interferon (IFN) and interferon-stimulated genes (ISGs) responses are counteracted What do interferons do in the immune system? Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they "interfere" with viruses and keep them from multiplying. This sequence of events, namely AECs infection, IFN signaling inhibition, and free viral replication depicts the viral vicious loop. It was not long before aircraft were shooting at each other, but the lack of any sort of steady point for the gun was a problem. The French solved this problem when, in late 1914, Roland Garros attached a fixed machine gun to the front of his plane, but while Adolphe Pegoud would become known as the first "ace", getting credit for five victories before also becoming the first ace to die in action, The second horseman: a gathering storm SARS-CoV-2 infects primarily airway and alveolar AECs, especially type II pneumocytes, the cells that produce alveolar surfactant and are predecessors of type I pneumocytes. However, it can infect any cell expressing the receptor ACE2. SARS-CoV-2, in the face of unchecked replication because of dampened innate immunity, can replicate in high titres early after the infection. Uncontrolled viral replication, because of a delayed innate immunity response, will cause cellular damage leading to an overexuberant and dysregulated immune kickback. This hyper reaction affecting the innate and adaptative immune responses will pave the way for immune-mediated damage of tissues and organs. The third horseman: a helpless lung Once SARS-CoV binds to its receptor, the abundance on the cell surface, mRNA expression, and the enzymatic activity of ACE2 are significantly reduced. Ang II activates several cellular functions and molecular signaling pathways related to tissue injury, inflammation, and fibrosis. They involve calcium mobilization, free radical generation, activation of protein kinases and nuclear transcription factors, recruitment of inflammatory cells, adhesion of monocyte and neutrophils to endothelial and mesangial cells, upregulation of adhesion molecules and stimulation of expression, synthesis, and release of cytokines and chemokines. The counterregulatory ACE2/Ang-(1–7)/Mas1R axis negatively modulates leukocyte migration, cytokine expression and release, and fibrogenesis pathways. The loss of ACE2 results in a overreaction, a uncontrolled immuneresponse against the virus. A cytokine storm. Resulting in enhanced inflammation and vascular permeability, leaving the lung defenceless in the face of the forthcoming raging cytokine storm. it is the host’s (patients) forces unchained by the pathogen’s presence, those which are to cause tissue and organ damage. Axis powers, coalition headed by Germany, Italy, and Japan that opposed the Allied powers in World War II. The alliance originated in a series of agreements between Germany and Italy, followed by the proclamation of an “axis” binding Rome and Berlin (October 25, 1936) Germany, Italy, and Japan now formed a triangle. The fourth horseman: an epidemic within the pandemic: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30262-0/fulltext Jeg ser et sambånd mellom Covid-19 som kommer fra flaggermusen og utviklingen innen luftfart. ACE2 som er genen, som vi arvt fra menneskene som levde i tiden for luftfartens begynnelse, er idag "åpen" for en virus fra Flaggermusen. Ser at i denna tid vi nu lever i, så har vi utviklet flyplan som idag nærmer seg flaggermusens evner (radar etc) Når vi nå nærmer oss flaggermusen evner, ser jeg som en mulighet at just dette er orsaken at vi nå er "åpne" via ACE2 genen, tils vi er i balanse, til og få Covid-19 fra Flaggermusen. Vi "matcher" (frekvensens) Bat Flight Inspires Next Generation of Wing Design https://interestingengineering.com/bat-flight-inspires-next-generation-of-wing-design Så på en måte er våre flyplan flaggermusen, og vi Sars-Cov. Den dagen vi lær oss at håndtere den, som Sars-Cov kan håndtere flaggermusen idag, i symbiose og uten og skade den. Frem hit, var ACE2 pilot for SarsCov
  3. Hvis du ser på min graf, så tror jeg vi er ved nr3-4 fra høyre, av pandemien.
  4. Tro? Det er en studie på gang, som gått inn i fas 2. Beregnet ferdig desember 06. De rekryterer pasienter akkurat nå.
  5. Mengden ACE2 reseptorer som Covid bruker som inngang i kroppen, har noe med Testosteron og gjøre. Det man veit er at når de tar bort Testosteron ur kroppen, forsvinner/minimeres og alle ACE2:ene. Der i kan forklaring ligge hvorfor barn klarer seg bedre. Når man blir eldre har man tydligvis flere av disse i lungene, og da har de med sykdommer, prostatacancer og gjøre. Studier pågår nå på amerikanske veteraner, der de tar bort Testosteron, gjør de androgyne, ur Covid-19 syke. Ju fler man har, desto værre blir sykdomsforløpet. Studien er inne i fas 2 og beregnes være ferdig til jul. I artikkelen her sier de at det meste er uklart, om ACE2. https://www.google.com/amp/s/theconversation.com/amp/what-is-the-ace2-receptor-how-is-it-connected-to-coronavirus-and-why-might-it-be-key-to-treating-covid-19-the-experts-explain-136928
  6. Hvit Russlands president sier at det egentlig rekker og sende en mms med screenshot på vaksinen til alle, så er de safe! I feel good!
  7. Pan "the whole" Demi "half"
  8. Ccr5/7 antagonist Despite that CCR5/7 are a key targets for HIV, Coronavirus, Cancer metastasis and many other diseases only few antagonists have been developed up to date for CCR5 and non for CCR7. However, one of CCR5 antagonists is under clinical trial in US now (phase 2). IncellDx’s evaluation of test results from the first four patients suggests immunological benefit within three days following treatment with leronlimab on all four patients and lower level of cytokine storm, especially IL-6 and TNF-α, which were reduced significantly https://www.cytodyn.com/newsroom/press-releases/detail/399/leronlimab-used-in-seven-patients-with-severe-covid-19
  9. Direkte latterlig og påstå noe sånt. De lær seg hver dag, og utbedrer behandlinger på sykehus over hele verden. The longest distance between 2 places is time. What is the longest distance between two points? Farthest-apart cities Rosario, Argentina to Xinghua, China: 19,996 km (12,425 mi) Lu'an, China to Río Cuarto, Argentina: 19,994 km (12,424 mi) Cuenca, Ecuador to Subang Jaya, Malaysia: 19,989 km (12,421 mi) Rancagua, Chile to Xi'an, China: 19,972 km (12,410 mi) https://en.m.wikipedia.org › wiki Extreme points of Earth - Wikipedia
  10. Supert! Som jeg sa før, er jeg ferdig med diskusjonen så langt. Venter på forskning som blir ferdig Og det har ikke bare med hydroxyklorokin og gjøre, men medisiner for og minske på dødeligheten av Covid -1.9 Bl.a noe mot Coronans antagonister, som i begynnelsen skaper forsinket immune response. Som i sin tur gir Coronan spillerom og etablere seg.
  11. Som sagt, jeg sier ikke at det er bevist at den fungerer. Finnes forskning på det, ikke att den ikke fungerer. Jeg mener at det finnes et motstand mot eventuelle medisiner som allerede er fremstilt mot andre sykdommer, som kan vise seg fungere mot Covid-19. Og at den motstanden forsinker studier og resultat. Her er et Svensk medisin, Anakinra som viser gode resultat mot Corona. Men hvor gode..? På vedlagt bilde, ser du at 8 pasienter fikk Anakinra, men 3 fikk corticosteroids i tillegg. 2 av de som fikk corticosteroids døde. Alle andre överlevde. Dette er problemet, at Hydroxychloroquine studier ikke har gjorts, riktig. Har vært tilleggsmedisinering, eller så mangler det noe som de mener skal være med. Og det er leger, som sier dette. Ikke noe kondpirationsteoretikere. Anakinra, a recombinant IL-1 receptor antagonist, has proven useful in a small retrospective study of COVID-19 patients with ARDS and hyper inflammation [153]. There are additional trials in progress with tocili- zumab, anakinra, and sarilumab. However, when trying to modify the cytokine response by targeting a single molecule or receptor, it should be recalled that the cytokine network is an intricate complex with a high degree of overlap, redundancy, and alternate pathways. This may explain therapy escape and eventually lack of response Hvordan tolker du dette..? "Chloroquine and its safer derivative hydroxychloro- quine are effective against SARS-CoV-2 in vitro [141]. However, recent news from the large Recovery trial showed that there is no beneficial effect of hydroxychloroquine in patients hospitalised with COVID-19; therefore, that arm of the study was stopped [142]. Other planned large trials, such as Solidarity, stopped enrolling patients to the hydroxychloroquine arm, and the National Institutes of Health- sponsored ORCHID study was also stopped [143,144]." https://www.researchgate.net/publication/343291958_The_four_horsemen_of_a_viral_Apocalypse_The_pathogenesis_of_SARS-CoV-2_infection_COVID-19 Motstanden mot alternativer for vaksiner, kan lignes ved immunforsvarets forsinkede naturlige reaksjon mot virus. Covid-19 forsinker og lurer immuneforsvaret som ikke reagerer mot viruset, (reagerer feil) i begynnelsen, og i sluttfasen av Covid-19 kan en overreaksjon, en Cytokinstorm, som er dødelig og skjer hos mange som leder av Covid-19, skje. Hva hvis deres vaksine kan lignes, på en Cytokinstorm? .
  12. Ja, man må hva for konspirationsteorier man vil om James Todaro. La oss vente på hva forsking har og si. Case closed for min del tils dess:)
  13. Dr Fauci på høringen: "...That was confounded by a number of issues, including the fact that many of the people who were receiving hydroxychloroquine were also receiving corticosteroids, which we know from another study, gives a clear benefit in reducing deaths with advanced disease. Men, er ikke dette og si, at corticosteroids fungerer, men hydroxychloroquine, fungerer ikke. I studien der de gav begge, til pasientene? Jeg har presentert til deg, forskning som viser hvordan corticosteroids, øker dødelighet blandt Covid-19 pasienter, i tidligere innlegg. Her: Impact of corticosteroid treatment on clinical outcomes of influenza-associated ARDS https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-0642-4 Despite Guidelines, Controversy Remains Over Corticosteroids in COVID-19 https://www.medscape.com/viewarticle/931505 Noterbart (Men ikke av verdi) är at hvis du ser video fra høringen, sier De Fauci, "..gives a de-clear benefit in reducing deaths with advanced disease..." Men synes det er litt morsomt... (sneaky) Du påstår, at med dagens forskningsresultat skal de som sier at hydroxychloroquine virker, i fengsel, for dissinfo?? Men Fauci er allright...? Men du presenterer ikke noe bevis.
  14. Ja, hvis Toledo i øyene av hans motstandere er og se som Coronan selv manifestert, må jeg si reaksjonen mot han og være en manifestasjon av en cytokinstorm, en overreaksjon av immunsystemet. Det eneste som er på etterslep er, (foruten at Corona orsaker at immuneforsvarets respons blir forsinket) en side innen politikken, som synes at det helger målet at gjøre akkurat sånn som Coronan gjør... for og prøve og vinne. Og kansje vi trenger en øyelege, som forteller oss ting forskjellig, fra media for øvrig... Det er en myte, at fladdermusen er blind.
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